# US 2010/0166885 A1 · Resuscitation Fluid > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2010/0166885 A1 - Document ID: US20100166885A1 - Status: Published application - Kind: A1 - Application number: 12/722,915 - Filed: 2010-03-12 - Published: 2010-07-01 - Earliest claimed: 2007-05-29 - Assignees: University of South Carolina - Inventors: Stephan Fann; Michael J. Yost - Web page: https://patentgrep.com/patent/US20100166885A1 ## CPC - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61K 31/221: with compounds having an amino group, e.g. acetylcholine, acetylcarnitine - A61K 33/14: Alkali metal chlorides; Alkaline earth metal chlorides - A61K 38/38: Albumins - A61K 38/385: {Serum albumin} - A61P 7/04: Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents - A61P 7/08: Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention relates to a resuscitation fluid which includes an ionic salt at a concentration above about 0.9%, at least one soluble protein, at least one intermediate energy substrate, and optionally an agent to mitigate intracellular acidosis. Methods of making and using the fluid are also described. ## Claims ### Claim at position 1 1-41. (canceled) ### Claim 42 A resuscitation fluid for treating hypovolemia in a subject, wherein the resuscitation fluid is a solution comprising: an ionic salt at a salt concentration between about 0.9% and about 15% by weight of the resuscitation fluid; a soluble protein at a protein concentration between about 15% and about 40% by weight of the resuscitation fluid; an intermediate energy substrate at an energy substrate concentration between about 0.1% and about 10% by weight of the resuscitation fluid; and water. ### Claim 43 (depends on 42) The resuscitation fluid according to claim 42 further comprising a buffer. ### Claim 44 (depends on 43) The resuscitation fluid according to claim 43, wherein the resuscitation fluid has a pH adjusted by the buffer to be between about 6.5 and about 7.0. ### Claim 45 (depends on 42) The resuscitation fluid according to claim 42, wherein the ionic salt has a salt concentration between about 5% and about 10% by weight of the resuscitation fluid. ### Claim 46 (depends on 42) The resuscitation fluid according to claim 42, wherein the protein concentration is between about 20% and about 30% by weight of the resuscitation fluid. ### Claim 47 (depends on 42) The resuscitation fluid according to claim 42, wherein the energy substrate concentration is between about 0.5% and about 2% by weight of the resuscitation fluid. ### Claim 48 (depends on 42) The resuscitation fluid according to claim 42 further comprising an agent to mitigate intracellular acidosis. ### Claim 49 (depends on 48) The resuscitation fluid according to claim 48, wherein the agent to mitigate intracellular acidosis is present in the resuscitation fluid at an agent concentration between about 0.2% and about 20% by weight of the resuscitation fluid. ### Claim 50 (depends on 48) The resuscitation fluid according to claim 48, wherein the agent concentration is between about 0.5% and about 4% by weight of the resuscitation fluid. ### Claim 51 (depends on 48) The resuscitation fluid according to claim 48, wherein the agent to mitigate intracellular acidosis is N-acetylcysteine. ### Claim 52 (depends on 42) The resuscitation fluid according to claim 42, wherein the soluble protein comprises albumin. ### Claim 53 (depends on 52) The resuscitation fluid according to claim 52, wherein the soluble protein comprises human serum albumin. ### Claim 54 (depends on 42) The resuscitation fluid according to claim 42, wherein the intermediate energy substrate comprises a keto-acid containing a ketone functional group and a carboxylic acid group. ### Claim 55 (depends on 42) The resuscitation fluid according to claim 42, wherein the intermediate energy substrate comprises a carboxylate anion of a keto-acid containing a ketone functional group and a carboxylic acid group. ### Claim 56 (depends on 42) The resuscitation fluid according to claim 42, wherein the intermediate energy substrate comprises pyruvate. ### Claim 57 (depends on 42) The resuscitation fluid according to claim 42, wherein the ionic salt comprises sodium chloride. ### Claim 58 A resuscitation fluid for treating hypovolemia in a subject, wherein the resuscitation fluid is a solution comprising; an ionic salt; a soluble protein, wherein the soluble protein comprises albumin; an intermediate energy substrate, wherein the intermediate energy substrate comprises pyruvate; an agent to mitigate intracellular acidosis, wherein the agent to mitigate intracellular acidosis comprises N-acetylcysteine; and water ### Claim 59 (depends on 58) The resuscitation fluid according to claim 58 further comprising a buffer, wherein the resuscitation fluid has a pH adjusted by the buffer to be between about 6.5 and about 7.0. ### Claim 60 (depends on 58) The resuscitation fluid according to claim 58, wherein the resuscitation fluid comprises the ionic salt between about 0.9% and about 15% by weight; albumin between about 15% and about 40% by weight; pyruvate between about 0.1% and about 10% by weight; and N-acetylcysteine between about 0.2% and about 20% by weight.