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US 2010/0166881 A1Published application
Novel IDO Inhibitors and Methods of Use Thereof
OwnerGeorge C. Prendergast, William P. Malachowski +2inventors
InventorsGeorge C. Prendergast, William P. Malachowski, Alexander J. Muller, James B. DuHadaway
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Abstract
Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.
Claims14
A compound having indoleamine 2,3 dioxygenase (IDO) inhibitory activity, said compound having the formula of:
- wherein R1 is cycloalkyl or aryl;
- R2 is alkenyl or —CH2—R4, wherein R4 is hydrogen or aryl;
- and n is 2 or 3;
- wherein when n is 2, R1 is selected from the group consisting of cycloalkyl, bicyclic aryl, heteroaryl, and a substituted aryl, wherein the substituent is selected from the group consisting of alkyl, halo, haloalkyl, alkylthio, hydroxyl, carboxyl, oxo, epoxy, alkyloxycarbonyl, alkylcarbonyloxy, amino, carbamoyl, urea, alkylurea, and thiol.
1 more element
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8-12. (canceled)
14-20. (canceled)
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Dependencies are inferred from the claim text.