# US 2010/0166833 A1 · Compositions, articles and methods for preventing or reducing tobacco-associated damage > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2010/0166833 A1 - Document ID: US20100166833A1 - Status: Published application - Kind: A1 - Application number: 12/588,825 - Filed: 2009-10-29 - Published: 2010-07-01 - Earliest claimed: 2007-05-07 - Assignees: Technion Research & Development Foundation Limited - Inventors: Moshe Gavish; Rafael M. Nagler - Web page: https://patentgrep.com/patent/US20100166833A1 ## CPC - A61K 31/195: having an amino group - A23G 3/36: characterised by the composition {containing organic or inorganic compounds} - A23G 4/06: characterised by the composition {containing organic or inorganic compounds} - A24B 15/32: by acyclic compounds - A24D 3/14: of organic materials as additive (of ion exchange materials A24D3/12) - A61P 9/00: Drugs for disorders of the cardiovascular system - A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis - A61P 11/00: Drugs for disorders of the respiratory system - A61P 35/00: Antineoplastic agents - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23G: COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF - A24B: MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF - A24D: CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES OF CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract Articles of manufacturing, methods, devices and compositions for preventing or reducing tobacco-associated damage in a subject, and which utilize a metal ion chelating agent, a copper chelating agent, a penicillamine and/or a structural analog of penicillamine, with and without an additional antioxidant, are disclosed. ## Claims ### Claim 1 An article of manufacturing comprising tobacco and a tobacco packaging material, wherein at least a portion of said tobacco and/or tobacco packaging material comprises an agent selected from the group consisting of penicillamine and a structural analog of penicillamine. ### Claim 2 (depends on 1) The article of manufacturing of claim 1, wherein said at least a portion of said tobacco and/or said tobacco packaging material is in contact with an aerodigestive tract of a subject using the article of manufacturing. ### Claim 3 (depends on 1) The article of manufacturing of claim 1, wherein said agent is penicillamine. ### Claim 4 (depends on 3) The article of manufacturing of claim 3, said agent is D-penicillamine. ### Claim 5 (depends on 1) The article of manufacturing of claim 1, wherein said at least a portion of said tobacco and/or said tobacco packaging material further comprises at least one additional agent capable of reducing or preventing tobacco smoke-associated damage in a subject using the article of manufacturing. ### Claim 6 (depends on 5) The article of manufacturing of claim 5, wherein said agent is desferal. ### Claim 7 An article of manufacturing comprising tobacco and an agent being incorporated in at least a portion of said tobacco, said agent being selected from the group consisting of penicillamine and a structural analog of penicillamine. ### Claim 8 (depends on 7) The article of manufacturing of claim 7, wherein said at least a portion of said tobacco is in contact with an aerodigestive tract of a subject using the article of manufacturing. ### Claim 9 (depends on 7) The article of manufacturing of claim 7, wherein said agent is penicillamine. ### Claim 10 (depends on 9) The article of manufacturing of claim 9, said agent is D-penicillamine. ### Claim 11 (depends on 7) The article of manufacturing of claim 7, wherein said at least a portion of said tobacco further comprises at least one additional agent capable of reducing or preventing tobacco smoke-associated damage in a subject using the article of manufacturing. ### Claim 12 (depends on 11) The article of manufacturing of claim 11, wherein said agent is desferal. ### Claim 13 An article of manufacturing comprising a tobacco packaging material and an agent being incorporated in at least a portion of said tobacco packaging material, said agent being selected from the group consisting of penicillamine and a structural analog of penicillamine. ### Claim 14 (depends on 13) The article of manufacturing of claim 13, wherein said at least a portion of said tobacco packaging material is in contact with an aerodigestive tract of a subject using the article of manufacturing. ### Claim 15 (depends on 13) The article of manufacturing of claim 13, wherein said agent is penicillamine. ### Claim 16 (depends on 15) The article of manufacturing of claim 15, said agent is D-penicillamine. ### Claim 17 (depends on 13) The article of manufacturing of claim 13, wherein said at least a portion of said tobacco packaging material further comprises at least one additional agent capable of reducing or preventing tobacco smoke-associated damage in a subject using the article of manufacturing. ### Claim 18 (depends on 17) The article of manufacturing of claim 17, wherein said agent is desferal. ### Claim 19 A method of treating or preventing a tobacco-associated damage in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an agent selected from the group consisting of penicillamine and a structural analog thereof, thereby treating or preventing the tobacco-associated damage. ### Claim 20 (depends on 19) The method of claim 19, further comprising administering to said subject at least one additional agent that is capable of reducing or preventing the tobacco-associated damage. ### Claim 21 (depends on 20) The method of claim 20, wherein said additional agent is an antioxidant. ### Claim 22 (depends on 21) The method of claim 21, wherein said antioxidant is desferal. ### Claim 23 A pharmaceutical composition comprising an agent selected from the group consisting of penicillamine and a structural analog thereof and a pharmaceutically acceptable carrier, the composition being packaged in a packaging material and identified in print, in or on said packaging material, for use in the treatment of a tobacco-associated damage. ### Claim 24 (depends on 23) The pharmaceutical composition of claim 23, further comprising at least one additional agent that is capable of reducing or preventing the tobacco-associated damage. ### Claim 25 An article of manufacturing comprising a filter and an agent comprised with said filter, said agent being selected from the group consisting of penicillamine and a structural analog of penicillamine and said filter being designed and configured so as to enable release of said agent therefrom when in use by a subject. ### Claim 26 An oral composition comprising an agent selected from the group consisting of penicillamine and a structural analog of penicillamine, the composition being in the form of a toothpaste, powder, liquid dentifrice, mouthwash, denture cleanser, chewing gum, lozenge, paste, gel or candy. ### Claim 27 A medical device comprising an agent selected from the group consisting of penicillamine and a structural analog of penicillamine, the medical device being designed and configured to deliver said agent to a bodily site. ### Claim 28 An article of manufacturing comprising tobacco and a tobacco packaging material, wherein at least a portion of said tobacco and/or tobacco packaging material comprises an agent, said agent being a metal ion chelating agent, said metal being a redox active metal that can assume at least two oxidations states other than 0. ### Claim 29 (depends on 28) The article of manufacturing of claim 28, wherein said at least a portion of said tobacco and/or said tobacco packaging material is in contact with an aerodigestive tract of a subject using the article of manufacturing. ### Claim 30 (depends on 28) The article of manufacturing of claim 28, wherein said at least a portion of said tobacco and/or said tobacco packaging material further comprises at least one additional agent capable of reducing or preventing tobacco smoke-associated damage in a subject using the article of manufacturing. ### Claim 31 (depends on 28) The article of manufacturing of claim 28, wherein said metal ion chelating agent is selected from the group consisting of penicillamine, trientine, ethylendiamine, diethylenetriamine, triethylenetetramine, triethylenediamine, aminoethylethanolamine, aminoethylpiperazine, pentaethylenehexamine, triethylenetetramine, captopril, N,N′-bis(3-aminopropyl)-1,3-propanediamine, N,N′-Bis(2-animoethyl)-1,3-propanediamine, 1,7-dioxa-4,10-diazacyclododecane, 1,4,8,11-tetraazacyclotetradecane-5,7-dione, 1,4,7-triazacyclononane, 1-oxa-4,7,10-triazacyclododecane, 1,4,8,12-tetraazacyclopentadecane, 1,4,7,10-tetraazacyclododecane, staurosporine aglycone, 4,5-dianilinophthalimide, 1,2-diaminobenzene and 1,10-phenanthroline. ### Claim 32 An article of manufacturing comprising tobacco and an agent being incorporated in at least a portion of said tobacco, aid agent being a metal ion chelating agent, said metal being a redox active that can assume at least two oxidations states other than 0. ### Claim 33 (depends on 32) The article of manufacturing of claim 32, wherein said at least a portion of said tobacco is in contact with an aerodigestive tract of a subject using the article of manufacturing. ### Claim 34 (depends on 32) The article of manufacturing of claim 32, wherein said at least a portion of said tobacco further comprises at least one additional agent capable of reducing or preventing tobacco smoke-associated damage in a subject using the article of manufacturing. ### Claim 35 (depends on 32) The article of manufacturing of claim 32, wherein said metal ion chelating agent is selected from the group consisting of penicillamine, trientine, ethylendiamine, diethylenetriamine, triethylenetetramine, triethylenediamine, aminoethylethanolamine, aminoethylpiperazine, pentaethylenehexamine, triethylenetetramine, captopril, N,N′-bis(3-aminopropyl)-1,3-propanediamine, N,N′-Bis(2-animoethyl)-1,3-propanediamine, 1,7-dioxa-4,10-diazacyclododecane, 1,4,8,11-tetraazacyclotetradecane-5,7-dione, 1,4,7-triazacyclononane, 1-oxa-4,7,10-triazacyclododecane, 1,4,8,12-tetraazacyclopentadecane, 1,4,7,10-tetraazacyclododecane, staurosporine aglycone, 4,5-dianilinophthalimide, 1,2-diaminobenzene and 1,10-phenanthroline. ### Claim 36 An article of manufacturing comprising a tobacco packaging material and an agent being incorporated in at least a portion of said tobacco packaging material, aid agent being a metal ion chelating agent, said metal being a redox active metal that can assume at least two oxidations states other than 0. ### Claim 37 (depends on 36) The article of manufacturing of claim 36, wherein said at least a portion of said tobacco packaging material is in contact with an aerodigestive tract of a subject using the article of manufacturing. ### Claim 38 (depends on 36) The article of manufacturing of claim 36, wherein said at least a portion of said tobacco packaging material further comprises at least one additional agent capable of reducing or preventing tobacco smoke-associated damage in a subject using the article of manufacturing. ### Claim 39 (depends on 36) The article of manufacturing of claim 36, wherein said tobacco packaging material comprises a filter and said agent is impregnated in a paper of said filter. ### Claim 40 (depends on 36) The article of manufacturing of claim 36, wherein said metal ion chelating agent is selected from the group consisting of penicillamine, trientine, ethylendiamine, diethylenetriamine, triethylenetetramine, triethylenediamine, aminoethylethanolamine, aminoethylpiperazine, pentaethylenehexamine, triethylenetetramine, captopril, N,N′-bis(3-aminopropyl)-1,3-propanediamine, N,N′-Bis(2-animoethyl)-1,3-propanediamine, 1,7-dioxa-4,10-diazacyclododecane, 1,4,8,11-tetraazacyclotetradecane-5,7-dione, 1,4,7-triazacyclononane, 1-oxa-4,7,10-triazacyclododecane, 1,4,8,12-tetraazacyclopentadecane, 1,4,7,10-tetraazacyclododecane, staurosporine aglycone, 4,5-dianilinophthalimide, 1,2-diaminobenzene and 1,10-phenanthroline. ### Claim 41 A method of treating or preventing a tobacco-associated damage in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an agent, aid agent being a metal ion chelating agent, said metal being a redox active metal that can assume at least two oxidations states other than 0. ### Claim 42 (depends on 41) The method of claim 41, further comprising administering to said subject at least one additional agent that is capable of reducing or preventing the tobacco-associated damage. ### Claim 43 (depends on 42) The method of claim 42, wherein said additional agent is an antioxidant. ### Claim 44 (depends on 21) The method of claim 21, wherein said antioxidant is desferal. ### Claim 45 (depends on 41) The method of claim 41, wherein said metal ion chelating agent is selected from the group consisting of penicillamine, trientine, ethylendiamine, diethylenetriamine, triethylenetetramine, triethylenediamine, aminoethylethanolamine, aminoethylpiperazine, pentaethylenehexamine, triethylenetetramine, captopril, N,N′-bis(3-aminopropyl)-1,3-propanediamine, N,N′-Bis(2-animoethyl)-1,3-propanediamine, 1,7-dioxa-4,10-diazacyclododecane, 1,4,8,11-tetraazacyclotetradecane-5,7-dione, 1,4,7-triazacyclononane, 1-oxa-4,7,10-triazacyclododecane, 1,4,8,12-tetraazacyclopentadecane, 1,4,7,10-tetraazacyclododecane, staurosporine aglycone, 4,5-dianilinophthalimide, 1,2-diaminobenzene, and 1,10-phenanthroline. ### Claim 46 A pharmaceutical composition comprising an agent and a pharmaceutically acceptable carrier, said agent being a metal ion chelating agent, said metal being a redox active metal that can assume at least two oxidations states other than 0, the composition being packaged in a packaging material and identified in print, in or on said packaging material, for use in the treatment of a tobacco-associated damage. ### Claim 47 (depends on 46) The pharmaceutical composition of claim 46, wherein said metal ion chelating agent is selected from the group consisting of penicillamine, trientine, ethylendiamine, diethylenetriamine, triethylenetetramine, triethylenediamine, aminoethylethanolamine, aminoethylpiperazine, pentaethylenehexamine, triethylenetetramine, captopril, N,N′-bis(3-aminopropyl)-1,3-propanediamine, N,N′-Bis(2-animoethyl)-1,3-propanediamine, 1,7-dioxa-4,10-diazacyclododecane, 1,4,8,11-tetraazacyclotetradecane-5,7-dione, 1,4,7-triazacyclononane, 1-oxa-4,7,10-triazacyclododecane, 1,4,8,12-tetraazacyclopentadecane, 1,4,7,10-tetraazacyclododecane, staurosporine aglycone, 4,5-dianilinophthalimide, 1,2-diaminobenzene, and 1,10-phenanthroline. ### Claim 48 (depends on 46) The pharmaceutical composition of claim 46, further comprising at least one additional agent that is capable of reducing or preventing said tobacco-associated damage. ### Claim 49 (depends on 48) The pharmaceutical composition of claim 48, wherein said additional agent is an antioxidant. ### Claim 50 (depends on 49) The pharmaceutical composition of claim 49, wherein said antioxidant is desferal. ### Claim 51 An article of manufacturing comprising a filter and an agent comprised with said filter, said agent being a metal ion chelating agent, said metal being a redox active metal that can assume at least two oxidations states other than 0 and said filter being designed and configured so as to enable release of said agent therefrom when in use by a subject. ### Claim 52 An article of manufacturing comprising a filter and an agent comprised with said filter, said agent being a metal ion chelating agent, said metal being a redox active metal that can assume at least two oxidations states other than 0 and said filter being designed and configured so as to enable release of said agent therefrom when in use by a subject. ### Claim 53 An oral composition comprising a metal ion chelating agent, said metal being a redox active metal that can assume at least two oxidations states other than 0, the composition being in the form of a toothpaste, powder, liquid dentifrice, mouthwash, denture cleanser, chewing gum, lozenge, paste, gel or candy. ### Claim 54 A medical device comprising a metal ion chelating agent, said metal being a redox active that can assume at least two oxidations states other than 0, the medical device being designed and configured to deliver said agent to a bodily site.