# US 2010/0166830 A1 · Bioactive Scaffold for Therapeutic and Adhesion Prevention Applications

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2010/0166830 A1
- Document ID: US20100166830A1
- Status: Published application
- Kind: A1
- Application number: 12/725,656
- Filed: 2010-03-17
- Published: 2010-07-01
- Earliest claimed: 2006-03-07
- Assignees: Axle International
- Inventors: Brendan A. Harley; Eric C. Soller; Eric Aiazian
- Web page: https://patentgrep.com/patent/US20100166830A1

## CPC

- A61K 9/0024: {Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L)}
- A61L 31/129: {containing macromolecular fillers}
- A61L 31/146: {Porous materials, e.g. foams or sponges}
- A61P 41/00: Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A device for inhibiting adhesion of apposing human body tissue layers includes a scaffold having a designated mean pore size, relative density, and degradation half-life. The scaffold may be operably positioned between apposing tissue layers, such as proximate adhesiogenic layers at a wound site, so as to permit remesothelialization of the tissue without formation of fibrous adhesions. The scaffold device of the invention inhibits adhesion formation by promoting contractile cell migration away from the wound site for a predetermined period of time. The invention further relates to device and methods for promoting internal tissue regeneration, and for provision and/or dispensation of therapeutic and/or diagnostic agents in vivo.

## Claims

### Claim 1

A device for inhibiting adhesion of apposing internal human body tissue layers, said device comprising:
a scaffold prepared by co-precipitation of collagen and a glycosaminonglycan, followed by lyophilization, said scaffold having first and second collagen-GAG copolymer portions, wherein said first collagen-GAG copolymer portion has a first mean pore size, and said second collagen-GAG copolymer portion has a second mean pore size, with said first mean pore size being substantially smaller than said second mean pore size.

### Claim 2 (depends on 1)

The device of claim 1 wherein said second collagen-GAG copolymer portion is substantially more liquid permeable than said first collagen-GAG portion.

### Claim 3 (depends on 1)

The device of claim 1, including a bioadhesive disposed on a first surface of said scaffold.

### Claim 4 (depends on 1)

The device of claim 1 wherein said scaffold has a predetermined half life of between about 1 and 6 weeks when disposed in vivo.