# US 2010/0166794 A1 · Plasmodium liver stage antigens

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- Number: US 2010/0166794 A1
- Document ID: US20100166794A1
- Status: Published application
- Kind: A1
- Application number: 12/722,439
- Filed: 2010-03-11
- Published: 2010-07-01
- Earliest claimed: 2005-09-30
- Assignees: Seattle Biomedical Research Institute; The USA, as Represented by the Secretary of the Army,on Behalf of the Walter Reed; Philadelphia Health & Education Corporation, D/B/A/ Drexel University College of Medicine Ducom
- Inventors: Patrick Duffy; Stefan H.I. Kappe; Urszula Krzych; Donald G. Heppner, JR.; Lawrence W. Bergman; Vladislav A. Malkov; Alice Tarun; Jason W. Wendler; Igor Bacik
- Web page: https://patentgrep.com/patent/US20100166794A1

## CPC

- C07K 14/445: Plasmodium
- A61P 33/06: Antimalarials
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.

## Claims

### Claim 1

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:11-44 and immunogenic derivatives thereof.

### Claim 2

An immunogenic composition comprising an isolated polypeptide and a pharmaceutically acceptable carrier, wherein the isolated polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:11-44 and immunogenic derivatives thereof.

### Claim 3

An isolated nucleic acid molecule encoding a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:11-44 and immunogenic derivatives thereof.