# US 2010/0166148 A1 · Orthovoltage radiotherapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2010/0166148 A1 - Document ID: US20100166148A1 - Status: Published application - Kind: A1 - Application number: 12/493,136 - Filed: 2009-06-26 - Published: 2010-07-01 - Earliest claimed: 2006-12-13 - Assignees: Oraya Therapeutics, Inc. - Inventors: Michael Gertner; Steven D. Hansen; Erik Chell; Mark Arnoldussen; Matt Herron - Web page: https://patentgrep.com/patent/US20100166148A1 ## CPC - A61N 5/1067: {in real time, i.e. during treatment} - A61B 6/506: {for diagnosis of nerves} - A61B 6/508: {for non-human patients} - A61N 5/10: X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy (A61N5/01 takes precedence) - A61N 5/1001: {using radiation sources introduced into or applied onto the body; brachytherapy} - A61N 5/1017: {Treatment of the eye, e.g. for "macular degeneration"} - A61N 5/1045: {using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT} - A61N 5/1048: {Monitoring, verifying, controlling systems and methods} - A61N 5/1049: {for verifying the position of the patient with respect to the radiation beam} - A61N 5/1064: {for adjusting radiation treatment in response to monitoring} - A61N 5/1065: {Beam adjustment} - A61N 5/1077: {Beam delivery systems} - A61N 5/1084: {for delivering multiple intersecting beams at the same time, e.g. gamma knives} - A61N 2005/1019: {Sources therefor} - A61N 2005/1022: {Generators, e.g. X-ray tubes} - A61N 2005/105: {using a laser alignment system} - A61N 2005/1051: {using an active marker} - A61N 2005/1059: {using cameras imaging the patient} - A61N 2005/1091: {Kilovoltage or orthovoltage range photons} - A61N 2005/1097: {Means for immobilizing the patient} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilised in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments. ## Claims ### Claim 1 A system, for treating a target tissue with x-ray radiation, comprising: a radiation source that emits x-rays, the x-rays having an energy between about 1 KeV and about 500 KeV; a collimator that collimates the emitted x-rays into an x-ray beam, the x-ray beam having a dose distribution at a beam spot in a plane at the target tissue, such that the x-ray beam has a penumbra at the target tissue of less than about 20 percent; an alignment system that aligns the x-ray beam with an axis traversing the target tissue and that positions the radiation source within about 50 cm from the target tissue; and a processing module that receives an input comprising a parameter of the target tissue and that, based on the parameter, outputs to the alignment system a direction for the x-ray beam to be emitted toward the target tissue. ### Claim 2 (depends on 1) The system of claim 1, wherein the alignment system is configured to align the x-ray beam repeatedly during a treatment session. ### Claim 3 (depends on 1) The system of claim 1, wherein the parameter comprises a location of a fiducial marker that provides indication of a location of the target tissue. ### Claim 4 A system, for treating a target tissue with x-ray radiation, comprising: a radiation source that emits x-rays, the x-rays having an energy between about 1 KeV and about 500 KeV; a collimator that collimates the x-rays into an x-ray beam, the radiation source comprising an imageable light source that indicates an approximate center of a beam spot of the x-ray beam at the target tissue; an alignment system that aligns the x-ray beam with an axis traversing the target tissue and that positions the radiation source in alignment with the target tissue such that a trajectory of the x-ray beam traverses the target tissue; and a processing module that receives an input comprising a parameter of the target tissue and that, based on the parameter, outputs to the alignment system a direction for the x-ray beam to be emitted toward the target tissue. ### Claim 5 (depends on 4) The system of claim 4, wherein the parameter comprises a location of a fiducial marker that provides indication of a location of the target tissue. ### Claim 6 (depends on 5) The system of claim 5, wherein the fiducial marker comprises a component of an eye holder that stabilises the eye during emission of the x-ray beam. ### Claim 7 (depends on 4) The system of claim 4, wherein the imageable light source comprises a laser. ### Claim 8 (depends on 4) The system of claim 4, wherein the alignment system further comprises a programmable electromotive system to move the x-ray source. ### Claim 9 (depends on 4) The system of claim 4, wherein the collimator is configured to collimate the x-ray beam such that the x-ray beam has a penumbra at the target tissue of less than about 20 percent. ### Claim 10 A system, for treating a target tissue with x-ray radiation, comprising: a radiation source; an alignment system, coupled to the radiation source, the alignment system having a coordinate system defining an axis traversing the target tissue; and a processing module that receives an input comprising a parameter of the target tissue and that, based on the parameter, outputs to the alignment system a direction for radiation emitted from the radiation source toward the target tissue. ### Claim 11 (depends on 10) The system of claim 10, wherein said target tissue comprises an eye and said axis traversing the target tissue is determined by an imaging system. ### Claim 12 (depends on 10) The system of claim 10, wherein said target tissue comprises an eye and said axis traversing the plane of the eye is determined by an anatomic feature of the eye. ### Claim 13 (depends on 10) The system of claim 10, wherein said processing module outputs a position for the radiation source. ### Claim 14 (depends on 10) The system of claim 10, wherein said axis comprises the geometric axis of the eye. ### Claim 15 (depends on 10) The system of claim 10, wherein said axis comprises the visual axis of the eye. ### Claim 16 (depends on 10) The system of claim 10, wherein said target tissue comprises an eye and said axis traversing the eye is determined by a fiducial on an eye holder.