Quantitative prediction method
AssigneeVicro Bvba
InventorsHerwig Gaston Emiel Van Marck, Tim Gerrit Van Den Bulcke, Hans Victor Vermeiren
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Abstract
The present invention concerns methods and systems for analysis of drug resistance in HIV-1. More specifically, the invention provides methods for predicting drug resistance by correlating genotypic information with phenotypic profiles. The methods allow the identification of primary and secondary resistance-associated mutations for new and existing drugs and for calculating the contribution of mutations and combinations of mutations to resistance and hyper-susceptibility. The invention allows the design, optimization and assessment of the efficiency of a therapeutic regimen based upon the genotype of the disease affecting a patient
Claims7
A computer-readable storage medium storing a means for:
- a) calculating quantitative contributions of a mutation pattern to drug resistance phenotypes exhibited by an HIV strain;
- and
- b) quantitating individual contributions of a mutation or combination of mutations to drug resistance phenotypes exhibited by an HIV strain;
- wherein the contributions of a) and b) are used in assessing, designing and optimizing efficiency of a therapeutic regimen based on the genotype of the HIV strain affecting a patient.
Dependencies are inferred from the claim text.