Biologically engineered stent
OwnerFrancisco Avellanetinventor
Life of this patent
Estimating the term…
Abstract
Biologically engineered stents are provided, some having novel double-walled and hybrid composition constructions that are suitable for multi-drug delivery. Some embodiments of biologically engineered stents (BES) in accordance with the invention can deliver drugs in the form of gene therapy vectors to cells in the walls of stented vessels, thereby promoting local production of therapeutic factors that attract and enhance the formation of endothelium in the stented vessel. Other embodiments of BES include xenografts, allografts or isografts comprising sleeve-like natural matrices derived from vessels of animal and human subjects including postmortem human donors.
Claims21
A double-walled stent comprising:
- an outer stent fabricated from a first core material;
- and
- an inner stent fabricated from a second core material, wherein the inner stent is disposed within the outer stent.
A hybrid stent comprising a mid-section and two or more end sections adjoined thereto, wherein the mid-section is fabricated from a core material that is a metal and the end sections are fabricated from a core material that is a polymer.
A biologically engineered stent (BES) for promoting formation of vascular endothelium in a blood vessel comprising:
- a core material and a drug-containing layer, wherein the drug-containing layer comprises a vector that includes a nucleic acid sequence encoding a factor that promotes attraction, differentiation, or proliferation of endothelial cells.
A biologically engineered stent (BES) for placement in a host blood vessel of a subject in need thereof, comprising:
- a core material;
- and
- a biological matrix derived from tissue of a mammal, said matrix being configured to oppose the intima of the host blood vessel upon implantation of the stent into said vessel.
Dependencies are inferred from the claim text.