Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents
AssigneeAlza Corporation
InventorsMahmoud Ameri, Michel J.N. Cormier, Yuh-Fun Maa, Marika Kamberi, Peter E. Daddona
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Abstract
An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
Claims14
A method of treating a patient having need of increased bone density comprising administering a PTH-based agent transdermally to said patient in an amount effective in increasing bone density, comprising the steps of:
- i) providing a device comprising a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient;
- wherein a biocompatible coating is disposed on said microprojection member, said coating being formed from a coating formulation comprising at least one PTH-based agent, and
- ii) applying said microprojection member of said device to a skin site of said patient, whereby said plurality of stratum corneum-piercing microprotrusions pierce the stratum corneum and deliver said PTH-based agent to said patient;
- wherein said method is effective in increasing bone in said patient.
Dependencies are inferred from the claim text.