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US 2010/0160850 A1Published application
Gels with predetermined conductivity used in electroporation of tissue
AssigneeThe Regents of the University of California
InventorsANTONI IVORRA, Boris Rubinsky
Life of this patent
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Abstract
Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
Claims22
A method of carrying out electroporation of tissue, comprising:
- inserting an electrically conductive gel into a vessel of a patient wherein the gel has a predetermined conductivity relative to surrounding tissue;
- placing an electrically conductive metal structure in the gel;
- positioning an electrode so that tissue to be electroporated is positioned between the gel and the electrode;
- applying current across the tissue to be electroporated in an amount so that cells of the tissue are subjected to electroporation.
1 more element
-17. (canceled)
A method of carrying out electroporation of tissue, comprising:
- inserting a gel into a patient by injection wherein the gel has a predetermined conductivity relative to surrounding tissue;
- applying current across tissue in an amount so that cells of the tissue are subjected to electroporation;
- wherein the conductivity of the gel is sufficiently below that of the surrounding tissue such that when current is applied substantially no current flows through the gel and the current is directed to a specific targeted area of tissue to be electroporated.
A method of carrying out electroporation of tissue, comprising:
- inserting a gel into tissue in a patient by injection wherein the gel has a predetermined conductivity relative to tissue surrounding the gel;
- applying current across tissue in an amount so that cells of the tissue are subjected to electroporation;
- wherein the conductivity of the gel is predetermined by incorporating a known concentration of ions in the gel.
Dependencies are inferred from the claim text.