Method and Apparatus for Quantification of Optical Properties of Superficial Volumes Using Small Source-to-Detector Separations
AssigneeThe Regents of the University of California
InventorsAnthony J. Durkin, Sheng-hao Tseng
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Abstract
A probe for obtaining quantitative optical properties and chromophore concentrations of tissue components in tissue in-vivo at superficial depths and at source-detector separations of 5 mm or less includes a source fiber providing light to expose the tissue, a diffuser layer into which light from the source fiber is directed and then from the diffuser layer to and/or into the tissue, and a detector fiber arranged relative to the diffuser layer for detecting backscattered and/or reflected light returned from the tissue without transmission through the diffuser layer.
Claims20
A probe for obtaining quantitative optical properties and chromophore concentrations of tissue components in tissue in-vivo at superficial depths and at source-detector separations of 5 mm or less comprising:
- a source fiber providing light to expose the tissue;
- a diffuser layer into which light from the source fiber is directed and then from the diffuser layer to and/or into the tissue;
- and
- a detector fiber arranged relative to the diffuser layer for detecting backscattered and/or reflected light returned from the tissue without transmission through the diffuser layer.
A method for self-calibrating a tissue probe having a plurality of source-detector pairs with a corresponding plurality of source-detector separation distances in which probe light from the source corresponding to each source-detector pair is transmitted through a diffuser layer, and in which probe each detector corresponding to each source-detector pair receives light from the tissue without transmission through the diffuser layer, the method comprising:
- selecting and measuring one of the plurality of source-detector pairs as a reference reflectance measurement;
- measuring and normalizing the reflectances from the remaining other ones of the plurality of source-detector pairs;
- and
- generating a corresponding plurality of normalized reflectance versus source-detector separation curves to fit the measurements obtained from the plurality of source-detector pairs included in the probe.
Dependencies are inferred from the claim text.