Chiral phosphoramides, chiral N-phosphonimines and methods for forming the same

Abstract

This application relates to the design and synthesis of new chiral imines reagents which can be utilized for the synthesis of chiral drugs and their precursors. It describes the design of the free NH2-group-attached chiral phosphoramides, a chiral N-phosphonimines and the methods for forming the same. The free NH2-group-attached chiral phosphoramides, having the structure of formula (I): wherein R1 and R2 are independently any organic groups. The synthesis of N-phosphoramides was performed starting from chiral 1,2-diamines via the following steps: N,N′-dialkylation consisting of aldehyde condensation and reduction, cyclization with phosphoryl halide, substitution of halide with azide anion and hydrogenation of azides. The N-phosphonyl imines are synthesized by condensation of N-phosphoramides with aldehydes. Quantitative yield was obtained for each of the four steps without special purification. All precursors were obtained as white solids. It should be addressed that after each application reaction of N-phosphonyl imines, N,N′-dialkyl vicinal diamine auxiliaries can be recovered quantitatively with one-time extraction using n-butanol and re-used.

Dependencies are inferred from the claim text.