Docetaxel polymorphs and processes
AssigneeDr. Reddy's Laboratories, Inc.
InventorsRaghavendracharyulu Venkata Palle, Sekhar Munaswamy Nariyam, Selvakumar Balaraman, Neelakandan Kaliaparumal
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Abstract
The present invention provides crystalline polymorphs of docetaxel and processes for preparing them, a method for preparing amorphous docetaxel, and a process for preparing docetaxel.
Claims27
A process for preparing docetaxel, comprising reacting a compound having a formula:
- with an acid, to form a compound having a formula:
A process for preparing crystalline Form I of docetaxel, comprising combining a solution of docetaxel in a ketone with an anti-solvent.
A process for preparing crystalline Form II of docetaxel, comprising combining a solution of docetaxel in acetonitrile with water.
A process for preparing crystalline Form III of docetaxel, comprising slurrying solid docetaxel in isopropyl alcohol.
A process for preparing crystalline Form IV of docetaxel, comprising combining a solution of docetaxel in N,N-dimethylformamide with water.
A process for preparing crystalline Form V of docetaxel, comprising combining a solution of docetaxel in tetrahydrofuran with toluene.
A process for preparing a crystalline polymorphic form of docetaxel, comprising:
- a) providing a solution of docetaxel in an organic solvent;
- b) removing solvent from the solution of a) for formation of crystals;
- and
- c) recovering a solid crystalline polymorph of docetaxel.
Crystalline Form I of docetaxel.
Crystalline Form II of docetaxel.
Crystalline Form III of docetaxel.
Crystalline Form IV of docetaxel.
Crystalline Form V of docetaxel.
Crystalline Form VI of docetaxel.
Crystalline Form VII of docetaxel.
Crystalline Form VIII of docetaxel.
Crystalline Form IX of docetaxel.
A process for preparing solid amorphous docetaxel, comprising combining a solution of docetaxel in tetrahydrofuran with an anti-solvent.
A process for preparing solid amorphous docetaxel, comprising removing solvent from a solution of docetaxel in an alcohol.
Dependencies are inferred from the claim text.