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US 2010/0160644 A1Published application
Novel processes of making hydroxy-1-azo-derivatives as tpo mimetics
OwnerJerome Francis Hayesinventor
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Abstract
Invented are novel processes of making hydroxy-1-azo-benzene derivatives as TPO mimetics. Also invented are novel intermediates used in the novel processes. Also invented are pharmaceutical compositions comprising compounds made by novel processes.
Claims5
A process for the preparation of a compound of formula I:
- wherein Z is COOH or tetrazol;
- or a pharmaceutically acceptable salt thereof, which
- comprises the steps of:
- (1) treating a compound of formula II:
- wherein X is Cl, Br, or I, Y is NO2 or NH2, and R is alkyl or substituted alkyl;
- with a Boronic acid in a solvent to form a compound of formula III:
- wherein Y is NH2 or NO2, and G is substituted aryl.
- (2) converting a compound of formula III to a compound of formula I;
- and
- thereafter optionally forming a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.