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US 2010/0160628 A1Published application
Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
AssigneeLes Laboratoires Servier
InventorsJean-Louis Peglion, Aimée Dessinges, Bernard Serkiz, Jean-Michel Lerestif, Jean-Pierre Lecouve
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Abstract
Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
Claims14
A process for the synthesis of a compound of formula (VI) in racemic or optically active form:
- wherein A represents H2C—CH2 or HC═CH,
- wherein a compound of formula (VII) in racemic or optically active form:
- is subjected to a reductive amination reaction with a compound of formula (VIII):
- in the presence of a reducing agent,
- in an organic solvent or a mixture of organic solvents.
2 more elements
A compound of formula (VII) in racemic or optically active form:
Dependencies are inferred from the claim text.