Intermediate compound of technetium nitride complex for radiodiagnostic imaging
AssigneeNihon Med-Physics Co., Ltd.
InventorsFrancesco Tisato, Fiorenzo Refosco, Cristina Bolzati, Stefania Agostini, Marina Porchia, Mario Cavazza-Ceccato, Shinji Tokunaga
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Abstract
A bisphosphonoaminc compound represented by the following formula (I): wherein R1, R2, R3, R4 and R5 are independently an alkyl group having 1 to 6 carbon atoms, and n is an integer of 1 to 6, is extremely useful as an intermediate for preparing a technetium nitride complex for radiodiagnostic imaging.
Claims13
A bisphosphonoamine compound represented by the following formula (I):
- wherein R1, R2, R3, R4 and R5 are independently an alkyl group having 1 to 6 carbon atoms, and n is an integer of 1 to 6.
A method for preparing a bisphosphonoamine compound represented by the formula (I), which comprises the step of:
- reacting a vinylphosphono compound of the following formula (II):
- wherein R1 and R2 are as defined above, with a phosphonoamine compound of the following formula (III):
- wherein R3, R4, R5 and n are as defined above, in the presence of a condensation reaction catalyst.
A method for preparing a bisphosphinoamine compound of the following formula (IV):
- wherein R5 and n are as defined above, R6 is an alkyl group having 1 to 6 carbon atoms, and m is an integer of 1 to 6, which comprises the steps of:
- reducing a bisphosphonoamine compound represented by the formula (I) with a reducing agent to produce a bisphosphineamine compound of the following formula (V)
- wherein R5 and n are as defined above, and
- reacting the compound of the formula (V) with a halogenated compound of the following formula (VI):
- X—(CH2)m—OR6 (VI)
- wherein X is a halogen atom, and R6 and m are as defined above.
Dependencies are inferred from the claim text.