Muteins of tear lipocalin with affinity for the t-cell coreceptor cd4
AssigneeTechnische Universität München
InventorsArne Skerra, Amber Nasreen
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Abstract
The present invention relates to a mutein of human tear lipocalin, wherein the mutein comprises at least one mutated amino acid residue at any two or more of the sequence positions 24-36, 53- 66, 79-84, and 102-110 (or 103-110) of the linear polypeptide sequence of the mature human tear lipocalin, and wherein the mutein binds to the extracellular region of the T-cell coreceptor CD4 with detectable affinity. The invention also relates to a method of generating such a mutein as well as to various pharmaceutical uses of such a mutein.
Claims46
A mutein of human tear lipocalin, wherein the mutein comprises at least one mutated amino acid residue at any two or more of the sequence positions 24-36, 53-66, 79-84, and 102-110 of the linear polypeptide sequence of the mature human tear lipocalin, and wherein the mutein binds to the extracellular region of the T-cell coreceptor CD4 with detectable affinity.
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Dependencies are inferred from the claim text.