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US 2010/0160610 A1Published application
Conjugates of an EPO Moiety and a Polymer
AssigneeNektar Therapeutics
InventorsMary J. Bossard, Gayle Stephenson
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Abstract
Conjugates of an EPO moiety and one or more non-peptidic water-soluble polymers are provided. Typically, the non-peptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of making conjugates, and methods of administering compositions comprising such conjugates to a patient.
Claims15
A method of preparing a conjugate of erythropoietin (EPO), said method comprising:
- reacting a polymer comprising the structure:
- wherein:
- POLY is a polyalkylene oxide,
- Q is an optional linking group having a length of from one to 10 atoms,
- m is an integer ranging from 0 to 20,
- Z is selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl, and
- X is a leaving group,
- with erythropoietin (EPO), under conditions effective to promote reaction of one or more amino sites on EPO with said polymer to thereby form a biologically active conjugate comprising the structure:
- where “—NH-EPO” represents an amino group of EPO.
6 more elements
Dependencies are inferred from the claim text.