p16 MEDIATED REGULATION OF NMDA RECEPTORS
OwnerNobuki Nakanishi, Gang Tong +1inventors
InventorsNobuki Nakanishi, Gang Tong, Shichun Tu
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Abstract
Discovered is a novel protein and variants thereof whose activity at the NMDA receptor causes an increased efflux of calcium ions through the channel of said receptor. This activity is downregulated by the NR3A subunit of NMDA. Also discovered are the nucleic acid sequences encoding said novel protein and variants thereof. The discovery is useful for the diagnosing of NMDA receptor dysregulation and the treatment of NMDA receptor dysregulation related disorders. In addition, the discovery is useful for the further discovery of modulators affecting the activity of the novel protein and variants thereof at the NMDA receptor.
Claims19
An isolated nucleic acid comprising the nucleic acid sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No.:
- 2, SEQ ID No.:
- 38, SEQ ID No.:
- 39, SEQ ID No.:
- 40, SEQ ID No.:
- 41, SEQ ID No.:
- 42, SEQ ID No.:
- 43, SEQ ID No.:
- 44, SEQ ID No.:
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- 54, SEQ ID No.:
- 55, SEQ ID No.:
- 56, SEQ ID No.:
- 57, SEQ ID No.:
- 58, SEQ ID No.:
- 59, SEQ ID No.:
- 60, SEQ ID No.:
- 61, SEQ ID No.:
- 62, SEQ ID No.:
- 63, SEQ ID No.:
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- 65, SEQ ID No.:
- 66, SEQ ID No.:
- 67, SEQ ID No.:
- 68, SEQ ID No.:
- 69, SEQ ID No.:
- 70, SEQ ID No.:
- 71, SEQ ID No.:
- 85, SEQ ID No.:
- 86, SEQ ID No.:
- 87, SEQ ID No.:
- 88, SEQ ID No.:
- 89 and SEQ ID No.:
- 90.
An isolated nucleic acid that hybridizes to a nucleic acid selected from the group consisting of SEQ ID No. 1, SEQ ID No.:
- 2, SEQ ID No.:
- 38, SEQ ID No.:
- 39, SEQ ID No.:
- 40, SEQ ID No.:
- 41, SEQ ID No.:
- 42, SEQ ID No.:
- 43, SEQ ID No.:
- 44, SEQ ID No.:
- 45, SEQ ID No.:
- 46, SEQ ID No.:
- 47, SEQ ID No.:
- 48, SEQ ID No.:
- 49, SEQ ID No.:
- 50, SEQ ID No.:
- 51, SEQ ID No.:
- 52, SEQ ID No.:
- 53, SEQ ID No.:
- 54, SEQ ID No.:
- 55, SEQ ID No.:
- 56, SEQ ID No.:
- 57, SEQ ID No.:
- 58, SEQ ID No.:
- 59, SEQ ID No.:
- 60, SEQ ID No.:
- 61, SEQ ID No.:
- 62, SEQ ID No.:
- 63, SEQ ID No.:
- 64, SEQ ID No.:
- 65, SEQ ID No.:
- 66, SEQ ID No.:
- 67, SEQ ID No.:
- 68, SEQ ID No.:
- 69, SEQ ID No.:
- 70, SEQ ID No.:
- 71, SEQ ID No.:
- 85, SEQ ID No.:
- 86, SEQ ID No.:
- 87, SEQ ID No.:
- 88, SEQ ID No.:
- 89 and SEQ ID No.:
- 90.
An isolated polypeptide having an amino acid sequence substantially similar to p16, wherein the isolated polypeptide has activity modulating cation efflux through the NMDA receptor.
The isolated polypeptide of claim 20 wherein a first isolated polypeptide is associated with a second isolated polypeptide.
The isolated polypeptide of claim 20 wherein the isolated polypeptide causes an increased efflux of cations through the NMDA receptor.
Dependencies are inferred from the claim text.