GLP-1 Fusion Peptides Conjugated to Polymer(s), Their Production and Use

The conjugate molecule containing a fusion peptide comprising as component (I) N-terminally a sequence according to formula II

• (SEQ ID NO:
• 44)
• Xaa7-Xaa8-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Xaa16-Ser-
• Xaa18-Xaa19-Xaa20-Glu-Xaa22-Xaa23-Ala-Xaa25-Xaa26-
• Xaa27-Phe-Ile-Xaa30-Trp-Leu-Xaa33-Xaa34-Xaa35-
• Xaa36-Xaa37,
• wherein Xaa7 is L-histidine, D-histidine, desamino-histidine, 2-amino-histidine, 3-hydroxy-histidine, homohistidine, N-acetyl-histidine, a-fluoromethyl-histidine, a-methyl-histidine, 3-pyridylalanine, 2-pyridylalanine or 4-pyridylalanine;
• Xaa8 is Ala, Gly, Val, Leu, Ile, Lys, Aib, (1-aminocyclopropyl) carboxylic acid, (1-aminocyclobutyl) carboxylic acid, (1-aminocyclopentyl) carboxylic acid, (1-aminocyclohexyl) carboxylic acid, (1-aminocycloheptyl) carboxylic acid, or (1-aminocyclooctyl) carboxylic acid, whereby Gly is particularly preferred;
• Xaa16 is Val or Leu;
• Xaa18 is Ser, Lys or Arg;
• Xaa19 is Tyr or Gln;
• Xaa20 is Leu or Met;
• Xaa22 is Gly, Glu or Aib;
• Xaa23 is Gln, Glu, Lys or Arg ;
• Xaa25 is Ala or Val ;
• Xaa26 is Lys, Glu or Arg;
• Xaa27 is Glu or Leu;
• Xaa30 is Ala, Glu or Arg;
• Xaa33 is Val or Lys;
• Xaa34 is Lys, Glu, Asn or Arg;
• Xaa35 is Gly or Aib;
• Xaa36 is Arg, Gly or Lys or amide or absent;
• Xaa37 is Gly, Ala, Glu, Pro, Lys, amide or is absent.
• or formula III
• (SEQ ID NO:
• 45)
• Xaa7-Xaa8-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-
• Xaa18-Tyr-Leu-Glu-Xaa22-Xaa23-Ala-Ala-Xaa26-Glu-
• Phe-Ile-Xaa30-Trp-Leu-Val-Xaa34-Xaa35-Xaa36-Xaa37,
• wherein Xaa7 is L-histidine, D-histidine, desamino-histidine, 2-amino-histidine, 3-hydroxy-histidine, homohistidine, N-acetyl-histidine, a-fluoromethyl-histidine, a-methyl-histidine, 3-pyridylalanine, 2-pyridylalanine or 4-pyridylalanine;
• Xaa8 is Ala, Gly, Val, Leu, Ile, Lys, Aib, (1-aminocyclopropyl) carboxylic acid, (1-aminocyclobutyl) carboxylic acid, (1-aminocyclopentyl) carboxylic acid, (1-aminocyclohexyl) carboxylic acid, (1-aminocycloheptyl) carboxylic acid, or (1-aminocyclooctyl) carboxylic acid;
• Xaa18 is Ser, Lys or Arg;
• Xaa22 is Gly, Glu or Aib;
• Xaa23 is Gln, Glu, Lys or Arg ;
• Xaa26 is Lys, Glu or Arg;
• Xaa30 is Ala, Glu or Arg;
• Xaa34 is Lys, Glu or Arg;
• Xaa35 is Gly or Aib;
• Xaa36 is Arg or Lys, amide or is absent;
• Xaa37 is Gly, Ala, Glu or Lys, amide or is absent.
• as component (II) C-terminally a peptide sequence of at least 9 amino acids or a functional fragment, variant or derivative thereof, and a synthetic or natural polymer.