Compositions, methods of use and preparation of 2,6-diisopropyl phenol and analogs for ischemic injury
AssigneeAbraxis BioScience, LLC
InventorsNeil P. Desai, Chunlin Tao, Cheng Zhi Yu, Vuong Trieu, Patrick Soon-Shiong
Life of this patent
Estimating the term…
Abstract
The present invention provides novel 2,6-diisopropyl phenol 2,6-diisopropyl phenol analogs and sterile, stable pharmaceutical compositions of 2,6-diisopropyl phenol 2,6-diisopropyl phenol and analogs thereof useful as an antioxidant in the treatment of ischemic injury including stroke and other cerebral injury. 2,6-diisopropyl phenol or its analogs are administered in a dosage effective to produce blood levels and brain levels of the drug that can prevent free radical damage associated with ischemic injury.
Claims32
A method of treating or preventing ischemic injury in a human, wherein the method comprises administering to the human an amount of a 2,6-diisopropyl phenol analog effective for the treatment of ischemic injury.
A method of providing an antioxidant to a human in need thereof, wherein the method comprises administering to the human an amount of a 2,6-diisopropyl phenol analog effective for obtaining an antioxidant effect.
A method of providing an antioxidant to the brain of a human, wherein the method comprises administering to the human a 2,6-diisopropyl phenol analog capable of crossing the blood-brain barrier.
A method for treating a sudden onset of at least one neurological deficit in a subject comprising administering an effective amount of a 2,6-diisopropyl phenol analog to a subject after the sudden onset of the neurological deficit.
A method of treating or preventing ischemic injury in a human with a pharmaceutical composition comprising:
- a) 0.5-5 wt % 2,6-diisopropyl phenol or an analog thereof, and
- e) 0.1-5 wt % oil,
- wherein, the composition is administered to a human in an amount effective to prevent or treat ischemia.
A method for preventing or treating ischemia in a human comprising administering to a human a low oil composition comprising 2,6-diisopropyl phenol or an analog thereof in an amount effective to prevent or treat ischemia.
A method of inducing sedation or sleep in a human in need thereof comprising administering to the human a 2,6-diisopropyl phenol analog.
Dependencies are inferred from the claim text.