Compounds useful for treating neurological disorders
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsMeir Bialer, Boris Yagen, Ilan Winkler, Marshall Devor
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Abstract
The invention relates to the use of compounds for the preparation of a medicament for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. The invention additionally relates to a pharmaceutical composition comprising compounds for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. A method for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration is also provided.
Claims12
A method for treating a psychiatric disorder in a mammal comprising administering to the mammal, a therapeutically effective amount of a compound of formula [A]
- as racemic mixtures or as individual stereoisomers or mixtures of racemic and stereoisomers,
- wherein
- (i) X is selected from OH and NR1R2;
- (ii) R1, R2 are independently selected from H and C1-C6 alkyl;
- (iii) n is 0 or 1;
- and
- (iv) (a) R3, R4 are independently selected from H and C1-C6 alkyl;
- R5, R6 are independently selected from H and C1-C6 alkyl;
- or
- (b) one of R3 and R4, together with one of R5 and R6, form a cyclopropyl ring, and the other of R3, R4, R5 and R6 is selected from H and C1-C6 alkyl,
- including pharmaceutically acceptable salts, hydrates and solvates of the compound of formula [A], with the exclusion of the following compounds in racemic and stereoisomeric forms for treating migraine:
- propylisopropyl acetic acid, propylisopropyl acetamide, valnoctamide, valnoctic acid, diisopropyl acetamide
- wherein R1 and R2 are independently selected from H and C1-C6 alkyl.
Dependencies are inferred from the claim text.