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US 2010/0160441 A1Published application
Novel compounds
AssigneeHoffmann-La Roche Inc.
InventorsTorsten Hoffmann, Holger Kuehne, Eric J. Niesor, Philippe Pflieger
Life of this patent
Estimating the term…
Abstract
The invention is concerned with compounds of formula I: wherein R, R2, and Q are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are useful as inhibitors of cholesteryl ester transfer protein (CETP).
Claims20
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R is selected from the group consisting of:
- (1) —SR1 wherein R1 is hydrogen or a C(O)C1-C10alkyl;
- and
- (2) a group of formula II:
- R2 is a C1-C10alkyl;
- Q is selected from the group consisting of:
- (1) a group of formula IIa:
- (2) a group of formula IIb:
- (3) a group of formula IIc:
- (4) a group of formula IId:
- and (5) a group of formula IIe:
- wherein X1, X2, X3, X4, X5 and X6 are independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C8cycloalkyl, halo-C1-C6alkyl, halo-C3-C8cycloalkyl, halo-C1-C6alkoxy, halogen, cyano, nitro, acyl and aryl;
- A is C—X1 or N;
- D is C—X2 or N;
- E is C—X3 or N;
- G is C—X4 or N;
- J is C—X1 or N;
- L is S, O or NH;
- and
- M is C—X2 or N;
- wherein in formula IIc at least one of A, D, E and G is N.
19 more elements
Dependencies are inferred from the claim text.