Methods and Compositions for the Treatment of Viral Infections

A method of preventing or treating flu or a flu-related condition comprising administering to a subject in need thereof a therapeutically effective amount of:

• (a) an M2 inhibitor;
• and
• (b) a neuraminidase inhibitor,
• wherein at least one of said M2 inhibitor or said neuraminidase inhibitor is provided in an extended release dosage form and wherein at least one of said active pharmaceutical ingredients in said extended release dosage form has an in vitro dissolution profile less than 70% in one hour, less than 90% in two hours, greater than 40% in six hours, and greater than 85% in 12 hours as measured using a USP type 2 (paddle) dissolution system at 50 rpm, at a temperature of 37±0.5° with water as a dissolution medium.

A pharmaceutical composition comprising:

• (a) amantadine in a dose ranging between 200 and 500 mg;
• and
• (b) oseltamivir in a dose ranging between 75 and 150 mg;
• wherein amantadine and oseltamivir are both provided in an extended release dosage form, said extended release dosage form having an in vitro dissolution profile less than 70% in one hour, less than 90% in two hours, greater than 40% in six hours, and greater than 85% in 12 hours as measured using a USP type 2 (paddle) dissolution system at 50 rpm, at a temperature of 37±0.5° with water as a dissolution medium;