Use of pol iii promoters for controlled expression of therapeutic proteins
AssigneeMax-Delbruck-Centrum fur Molekulare Medizin
InventorsJehad Charo, Thomas Blankenstein
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to the field of molecular biology. More specifically, the present invention relates to expression systems for use in modulating the expression of protein coding target genes in vivo or in vitro. More specific, this invention relates to RNA polymerase III-based methods and systems for expression of therapeutic proteins in cells in vivo or in vitro.
Claims13
Gene therapy-construct for the expression and/or transcriptional termination of protein coding genes comprising a RNA pol III dependent promoter sequence.
Method for controlled protein expression in vivo or in vitro,
- characterized in that
- a RNA pol III dependent promoter sequence is used for the protein expression.
Use of pol III promoters or their derivatives for gene therapy and application related to gene expression for therapeutic purposes.
Dependencies are inferred from the claim text.