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US 2010/0160411 A1Published application
Benzoxathiine and benzoxathiole derivatives and uses thereof
AssigneeWyeth
InventorsGary Paul Stack, Ivana Bianchi, Stefania Vallese, Giovanna Luoni
Life of this patent
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Abstract
Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided, wherein each of R1, R2, R3, R4, y, n, m, p, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
Claims33
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- p is 0, 1, or 2;
- m is 1 or 2;
- n is 0 or 1;
- Ar is phenyl, an 8-10 membered bicyclic partially unsaturated or aryl carbocyclic ring, a 5-6 membered monocyclic heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic partially unsaturated or heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein Ar is optionally substituted with one or more Rx groups;
- each Rx is independently selected from —R, —CN, halogen, —OR, —O(C1-6 haloalkyl), —C(O)NH2, —C(O)OR, C1-6 haloalkyl, —NHC(O)R, —SO2R, or —NHSO2R;
- y is 0-3;
- each R1 is independently —R, —CN, halogen, —OR, —O(C1-6 haloalkyl), —C(O)NH2, —C(O)OR, C1-6 haloalkyl, —NHC(O)R, —SO2R, or —NHSO2R;
- each R is independently hydrogen or C1-6 aliphatic;
- each of R2, R3 and R4 is independently R or C1-6 haloalkyl.
7 more elements
(canceled)
Dependencies are inferred from the claim text.