Bisbenzimidazoles as antimalarial agents
OwnerTien Huang, Jean Jacques Vanden Eynde +2inventors
InventorsTien Huang, Jean Jacques Vanden Eynde, Aurelie Pietka, Annie Mayence
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Abstract
The present invention relates to antimalarial agents. In particular, the present invention relates to the use of bisbenzimidazoles of Formula I for the prevention and/or treatment of malaria, wherein n is an integer selected from 0 to 10, and R1 and R2 are each independently selected from hydrogen, halogen, hydroxyl, alkyl, alkoxy, amino, alkylamino, alkylcarbonylamino, alkylcarbonyloxy, formyl, alkylcarbonyl, alkyloxycarbonyl, halocarbonyl, haloalkyl, haloalkoxy, carbamoyl, cyano, nitro, sulfo, or a carboxyl group.
Claims17
Use of at least one compound of formula I or a pharmaceutically acceptable salt or solvate thereof for the preparation of a medicament for the prevention and/or treatment of malaria,
- wherein n is an integer selected from 0 to 10, and
- R1 and R2 are each independently selected from hydrogen, halogen, hydroxyl, alkyl, alkoxy, amino, alkylamino, alkylcarbonylamino, alkylcarbonyloxy, formyl, alkylcarbonyl, alkyloxycarbonyl, halocarbonyl, haloalkyl, haloalkoxy, carbamoyl, cyano, nitro, sulfo, or a carboxyl group.
- Use according to claim 1, wherein n is 0, 1, 2, 3, 4, 5, 6 or 7.
Use according to claim 1 or 2, wherein R1 and R2 are each independently hydrogen, hydroxyl, halogen, alkyl, alkylamino, alkoxy, haloalkyl, haloalkoxy, alkyloxycarbonyl,
alkylcarbonyl, amino, cyano, nitro or a carboxyl group.
A method for the therapeutic and/or prophylactic treatment of malaria in a subject in need of such treatment comprising administering to the subject a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt or solvate thereof
- wherein
- n is an integer selected from 0 to 10, and
- R1 and R2 are each independently selected from hydrogen, halogen, hydroxyl, alkyl, alkoxy, amino, alkylamino, alkylcarbonylamino, alkylcarbonyloxy, formyl, alkylcarbonyl, alkyloxycarbonyl, halocarbonyl, haloalkyl, haloalkoxy, carbamoyl, cyano, nitro, sulfo, or a carboxyl group.
Dependencies are inferred from the claim text.