Oxazole derivatives and their use in the treatment of diabetes and obesity

A compound of formula (I)

• or a salt thereof, wherein:
• R1 is an optionally substituted aryl or optionally substituted heteroaryl group, wherein the optional substituents are one or more selected from —Za, —X2—(CR52R53)w—Za, —X2—(CR52R53)a—X3—Za, —(CR52R53)aX3—Za or a functional group other than —X2—(CR52R53)w—Za or —X2—(CR52R53)a—X3—Za);
• T is N, CH or CMe;
• Y is a direct bond, (CR40R41)s or —X6(CR40R41)t—;
• each R40 and R41 is independently selected from hydrogen, (1-4C)alkyl, hydroxy, halo, halo(1-4C)alkyl, amino, cyano, (1-4C)alkoxy, (1-4C)haloalkoxy or ((1-3C)alkyl)CONH;
• s is 1 to 6;
• t is 1 to 6, provided that the X6 atom of —X6(CR40R41)t— is attached to R2 and that a single sp3 hybridised carbon atom does not carry two or more bonds to a heteroatom unless the heteratom is a halo;
• R2 is an optionally substituted aryl, an optionally substituted cycloalkyl or an optionally substituted heterocyclic group, wherein optional substitutents are one or more selected from —Z, —X—(CR42R43)u—Z, —X—(CR42R43)v—X1—Z, —(CR42R43)vX1—Z or a functional group (other than —X—(CR42R43)u—Z or —X—(CR42R43)v—X1—Z);
• wherein Z and Za are independently selected from a hydrocarbyl group or a heterocyclic group or a combination thereof, wherein Z and Za is are optionally substituted on any available atom by one or more functional groups, or by —X7—(CR62R63)bR64;
• X, X1, X2, X3, X6 and X7 are linking groups independently selected from —C(O)x—, —O—, —S(O)y—, —NR44—, —C(O)NR44—, —OC(O)NR44—, —CH═NO—, —NR44C(O)x—, —NR44—, —S(O)2NR44— and —NR44S(O)2—;
• x is an integer of 1 or 2,
• y is 0, 1 or 2, and
• R44 and R45 are independently selected from hydrogen and (1-6C)alkyl,
• u and w are independently 0 to 6;
• v, a and b are independently 1 to 6;
• each R42, R43, R52, R53, R62 and R63 is independently selected from hydrogen, (1-4C)alkyl, hydroxy, halo, halo(1-4C)alkyl, amino, cyano, (1-4C)alkoxy, (1-4C)haloalkoxy, ((1-3C)alkyl)CONH—, carboxy, —SO3H, —S(O)2NHR13, —S(O)2NHC(O)R13, —CH2S(O)2R13, —C(O)NHS(O)2R13, —C(O)NHOH, —C(O)NHCN, —CH(CF3)OH, C(CF3)2OH, —P(O)(OH)2 and a 5-membered heterocyclic ring selected from the group consisting of
• R13 is (1-6C)alkyl, aryl or heteroaryl;
• R27 is hydrogen or (1-4C)alkyl;
• R64 is a functional group selected from carboxy, halo, halo(1-6C)alkyl, cyano, nitro, —C(O)nR20, —OR20, —S(O)mR20, —OS(O)2R20, —NR21R22, —C(O)NR21R22, —OC(O)NR21R22, —CH═NOR20, —NR21C(O)nR20, —NR20CONR21R22, —N═CR21R22, —S(O)2NR21R22, —NR21S(O)2R22, —SO3H, —S(O)2NHR13, —S(O)2NHC(O)R13, —CH2S(O)2R13, —C(O)NHS(O)2R13, —C(O)NHOH, —C(O)NHCN, —CH(CF3)OH, —C(CF3)2OH, —P(O)(OH)2 and the 5-membered heterocyclic ring as defined above;
• R20, R21 and R22 are independently selected from hydrogen, optionally substituted hydrocarbyl or optionally substituted heterocyclyl, or R21 and R22 together with the nitrogen atom to which they are attached form an optionally substituted ring having from 3 to 10 atoms, which optionally contains S(O)m, oxygen or nitrogen;
• n is 1 or 2;
• and
• m is 0-2.