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US 2010/0160388 A1Published application
Dihydropyridone ureas as p2x7 modulators
AssigneeRoche Palo Alto LLC
InventorsChristine E. Brotherton-Pleiss, Joan Marie Caroon, Francisco Javier Lopez-Tapia
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Abstract
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
Claims30
A compound of formula I:
- or pharmaceutically acceptable salts thereof,
- wherein:
- m is 0 or 1;
- n is 0 or 1;
- R1 is:
- optionally substituted aryl;
- optionally substituted heteroaryl;
- or
- adamantyl;
- R2 is:
- optionally substituted aryl;
- optionally substituted heteroaryl;
- C3-6cycloalkyl;
- C1-6alkyl;
- or
- C3-6 branched alkyl;
- and
- R3, R4 and R5 each independently is:
- hydrogen;
- or
- C1-6alkyl.
18 more elements
Dependencies are inferred from the claim text.