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US 2010/0160386 A1Published application
4-phenoxy-nicotine acid derivatives and use thereof as ppar-modulators
AssigneeBayer Schering Pharma Aktiengesellschaft
InventorsHeinrich Meier, Peter Kolkhof
Life of this patent
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Abstract
The present invention relates to novel 4-phenoxy-6-phenyl- and 4-phenoxy-6-pyridylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, especially of dyslipidemias, arteriosclerosis and heart failure.
Claims12
A compound of the formula (I)
- in which
- R1 is halogen, cyano or (C1-C4)-alkyl,
- R2 is a substituent selected from the group of halogen, cyano, (C1-C6)-alkyl, (C1-C6)-alkoxy and —NR9—C(═O)—R10, in which alkyl and alkoxy may in turn be substituted by hydroxyl, (C1-C4)-alkoxy, amino, mono-(C1-C4)-alkylamino or di-(C1-C4)-alkylamino, or up to pentasubstituted by fluorine, and
- R9 is hydrogen or (C1-C6)-alkyl
- and
- R10 is hydrogen, (C1-C6)-alkyl or (C1-C6)-alkoxy,
- n is 0, 1, 2 or 3,
- where, in the case that the substituent R2 occurs more than once, its definitions may be identical or different,
- A is N or C—R7,
- R3 is hydrogen or fluorine,
- R4 is hydrogen, fluorine, chlorine, cyano or (C1-C4)-alkyl,
- R5 is hydrogen, halogen, nitro, cyano, amino, trifluoromethyl, (C1-C4)-alkyl, trifluoromethoxy or (C1-C4)-alkoxy,
- R6 and R7 are the same or different and are each independently hydrogen, halogen, nitro, cyano, (C1-C6)-alkyl or (C1-C6)-alkoxy, in which alkyl and alkoxy may in turn be substituted by hydroxyl, (C1-C4)-alkoxy, amino, mono-(C1-C4)-alkyl-amino or di-(C1-C4)-alkylamino or up to pentasubstituted by fluorine,
- and
- R8 is hydrogen, methyl or trifluoromethyl,
- and the salts, solvates and solvates of the salts thereof.
13 more elements
(canceled)
Dependencies are inferred from the claim text.