Dihydropyridone amides as p2x7 modulators

A compound of formula I:

• or pharmaceutically acceptable salts thereof,
• wherein:
• m is 0 or 1;
• n is 0 or 1;
• p is from 0 to 4;
• q is 0 or 1;
• R1 is:
• hydrogen;
• C1-6alkyl;
• hydroxy-C1-6alkyl;
• C1-6alkoxy-C1-6alkyl;
• hydroxy C1-6alkoxy-C1-6alkyl;
• or
• aminocarbonyl-C1-6alkyl;
• R2 is:
• optionally substituted aryl;
• optionally substituted heteroaryl;
• C3-6cycloalkyl;
• or
• C1-6alkyl;
• and
• R3 is:
• hydrogen;
• C1-6alkyl;
• alkylcarbonylalkyl;
• or
• alkoxycarbonylalkyl;
• R4 and R5 each independently is:
• hydrogen;
• or
• C1-6alkyl;
• each R6 is independently:
• halo;
• C1-6alkyl;
• C1-6alkoxy;
• halo-C1-6alkyl;
• halo-C1-6alkoxy;
• C1-6alkylsulfonyl;
• C1-6alkylsulfanyl;
• C1-6alkylsulfinyl;
• phenylsulfonyl wherein the phenyl portion is optionally substituted with C1-6alkyl;
• nitrile;
• hydroxy;
• C1-6alkylcarbonyl;
• aminocarbonyl;
• C1-6alkoxycarbonyl;
• C1-6alkoxycarbonyl-C1-6alkoxy;
• hydroxycarbonyl;
• hydroxycarbonyl-C1-6alkoxy;
• C1-6alkylaminocarbonyl-C1-6alkoxy;
• C1-6alkoxy-C1-6alkoxy;
• hydroxy-C1-6alkoxy;
• C1-6alkylamino-C1-6alkoxy;
• C1-6alkylsulfonyl-C1-6alkoxy;
• hydroxy-C1-6alkyl;
• C3-6cycloalkyl-C1-6alkoxy;
• amino;
• amino-C1-6alkyl;
• C1-6alkenyl;
• C1-6alkynyl;
• morpholinyl;
• morpholinyl-C1-6alkyl;
• piperazinyl;
• piperidinyloxy;
• aminocarbonyl-C1-6alkoxy;
• C1-6alkoxyamino-C1-6alkyl;
• hydroxy-C1-6alkylamino-C1-6alkyl;
• C1-6alkoxycarbonylamino-C1-6alkyl;
• C1-6alkylcarbonylamino-C1-6alkyl;
• C1-6alkylaminocarbonyl;
• C1-6alkoxycarbonylC1-6alkyl;
• C1-6alkylaminocarbonyl-C1-6alkyl;
• C1-6alkylamino-C1-6alkyl;
• hydroxycarbonyl-C1-6alkyl;
• hydroxy C1-6alkoxy-C1-6alkyl;
• or nitro;
• or two adjacent substituents may form a C1-2alkylenedioxy or halo-C1-2alkylenedioxy;
• and
• A is a five or six membered heteroaryl ring that is optionally substituted.