Compositions for drug administration
AssigneeAegis Therapeutics, LLC
InventorEdward T. Maggio
Life of this patent
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Abstract
The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject, as well as compositions and methods for providing migraine pain relief. The compositions include at least one alkyl glycoside and at least one therapeutic agent, such as a 5-HT receptor agonist, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms.
Claims60
A composition comprising:
- a) a therapeutically effective amount of a 5-HT receptor agonist;
- and
- b) an alkylsaccharide.
A method of providing a reduced but therapeutically effective amount of a 5-HT agonist to a subject comprising administering a composition, the composition comprising:
- i) a therapeutically effective amount of a 5-HT receptor agonist;
- and
- ii) an alkylsaccharide,
- wherein the AUC is about equal as compared to the AUC provided by an increased therapeutically effective amount of 5-HT agonist administered in the absence of alkylsaccharide.
A method of providing rapid onset of migraine pain relief in a subject comprising administering a composition, the composition comprising:
- a) a therapeutically effective amount of a 5-HT receptor agonist;
- and
- b) an alkylsaccharide,
- wherein the composition exhibits a Tmax of about 30 minutes or less in the subject, thereby providing rapid onset of migraine pain relief.
A method of providing a reduced incidence of migraine pain recurrence in a subject comprising administering a composition, the composition comprising:
- a) a therapeutically effective amount of a 5-HT receptor agonist;
- and
- b) an alkylsaccharide,
- wherein the composition provides a Tmax of less than about 20 minutes, thereby providing a reduced incidence of migraine pain recurrence in the subject.
Dependencies are inferred from the claim text.