Deposition of nanocrystalline calcite on surfaces by a tissue and cellular biomineralization
OwnerAndrew S. Mount, Neeraj V. Gohad +3inventors
InventorsAndrew S. Mount, Neeraj V. Gohad, Douglas C. Hansen, Karolyn Mueller, Mary Beth Johnstone
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Abstract
Disclosed are articles comprising layered nanocrystalline calcite and methods for forming nanocrystalline calcite layers and compositions comprising nanocrystalline calcite layers.
Claims31
A process of depositing nanocrystalline calcite on a solid surface, comprising contacting the solid surface with an isolated mollusk cell, wherein the cell deposits nanocrystalline calcite on the solid surface.
A process of depositing nanocrystalline calcite on a solid surface, comprising contacting the solid surface to oyster mantle, wherein the oyster mantle deposits nanocrystalline calcite on the solid surface.
A process for forming nanocrystalline calcite layer comprising:
- a) contacting a surface with an isolated mollusk cell;
- and
- b) forming a nanocrystalline calcite deposit on the surface.
A process for preparing a synthetic pearl, comprising:
- a) contacting a suitable solid with oyster mantle;
- and
- b) forming a synthetic pearl comprising layered nanocrystalline calcite.
A process for forming a biocompatible surface on an inert surface, comprising:
- a) contacting an inert surface with a source of refractive hemocytes;
- b) exposing the inert surface in contact with the refractive hemocytes to viable oyster mantle;
- and
- c) forming a biocompatible nanocrystalline calcite layer on the inert surface;
- wherein formation of the calcite layer is induced by stimulating an immune response thereby increasing the number of refractive hemocytes.
A process for forming a biocompatible surface on an inert surface, comprising:
- a) contacting an inert surface with a mollusk shell;
- b) stimulating an immune response by manipulating the surface of the shell in the presence of refractive hemocytes;
- and
- c) forming a biocompatible nanocrystalline calcite layer on the inert surface.
A medical device for implantation into a human or a mammal having biocompatible surface formed by the process according to any of the above claims.
Dependencies are inferred from the claim text.