Analytical carrier and application thereof
AssigneeIbiden Co., Ltd.
InventorsSeijiro Anahara, Akihiko Moriyama
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Abstract
A carrier that is intended for retaining a subject of analysis and contains an electrically conductive material having a nonmetallic matrix. This analytical carrier containing an electrically conductive material is useful in situations where operations of the carrier, such as applying voltage thereto, are necessary to feed, retain or analyze the subject of analysis. The analytical carrier according to the present invention can be used as, for example, an alternate or a part of a metal sample plate for MALDI-TOFMS or other mass spectrometric analyses.
Claims31
An analytical carrier for retaining a subject of analysis, comprising an electrically conductive material having a nonmetallic matrix.
An analytical carrier for retaining a subject of analysis, comprising an electrically conductive material having a nonmetallic matrix, wherein the analytical carrier has corrosion resistance in Edman degradation and is capable of retaining a by-product of Edman degradation.
An analytical carrier retaining one or more subjects of analysis, comprising an electrically conductive polymer material dispersed in a nonmetallic matrix.
A method for mass spectrometry, comprising a step of ionization based on laser desorption using a carrier, which is an electrically conductive material having a nonmetallic matrix, for retaining a subject of analysis.
A method for analyzing a protein or a peptide, comprising:
- (a) a step of feeding the protein or the peptide onto a carrier and retaining the protein or the peptide on the carrier that is an electrically conductive material having a nonmetallic matrix;
- (b) a step of chemically modifying a terminal amino acid residue of a part of the protein or the peptide retained on the carrier so as to remove the terminal amino acid residue;
- and
- (c) a step of mass spectrometry of a fragment obtained in the step (b), which has the terminal amino acid removed, and a part of the protein or the peptide that has been modified but not cleaved in the step (b) while both are retained on the carrier.
Dependencies are inferred from the claim text.