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US 2010/0146652 A1Published application
Xenobiotic related induction of gene expression
AssigneeThe University of Sydney
InventorsChristopher LIDDLE, Bryan James Goodwin
Life of this patent
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Abstract
An isolated nucleic acid molecule comprising a nucleotide sequence encoding a transcriptional enhancer of cytochrome P450 (P450) CYP3A4 production or expression, and uses of the nucleic acid molecule for screening compounds for xenobiotic induction of CYP3A4 expression in cells and animals.
Claims12
1-21. (canceled)
An isolated nucleic acid molecule including a nucleotide sequence forming a transcriptional enhancer of cytochrome P450 CYP3A4 production or expression, the nucleic acid molecule including each of the following nuclear receptor response elements from the 5′-flanking region of CYP3A4:
- TGAACT(n)3TGACCC, TGAAAT(n)6GGTTCA, TGAATC(n)6TGAACT and TATTGT(n)3TGAACT, wherein n is adenine (A), guanine (G), thymine (T) or cytosine (C).
Dependencies are inferred from the claim text.