Method of monitoring retinopathy
OwnerLang Zhuo, Gideon Ho +1inventors
InventorsLang Zhuo, Gideon Ho, Saravana Kumar
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Abstract
There is presently provided methods of monitoring retinopathy in a live transgenic, non-human animal, the methods comprising providing a live transgenic non-human animal having a retinal pathology or a pre-disposition for a retinal pathology, wherein a nucleic acid molecule encoding a fluorescent protein under control of a GFAP promoter is integrated into the genome of the transgenic non-human animal; and detecting in vivo in the retinal glia of the transgenic non-human animal fluorescence levels of the fluorescent protein.
Claims22
A method for monitoring retinopathy, comprising:
- providing a live transgenic non-human animal having a retinal pathology or a pre-disposition for a retinal pathology, wherein a nucleic acid molecule encoding a fluorescent protein under control of a GFAP promoter is integrated into the genome of the transgenic non-human animal;
- and
- detecting in vivo in the retinal glia of the transgenic non-human animal a first fluorescence level of the fluorescent protein at a first time point and a second fluorescence level of the fluorescent protein at a second time point.
A method for monitoring retinopathy, comprising:
- providing a live first transgenic non-human animal having a retinal pathology or a pre-disposition for a retinal pathology, wherein a nucleic acid molecule encoding a fluorescent protein under control of a GFAP promoter is integrated into the genome of the first transgenic non-human animal;
- providing a live second transgenic non-human animal that is free from a retinal pathology or a pre-disposition for a retinal pathology, wherein a nucleic acid molecule encoding a fluorescent protein under control of a GFAP promoter is integrated into the genome of the second transgenic non-human animal;
- and
- detecting in vivo in the retinal glia of the first transgenic non-human animal a first fluorescence level of the fluorescent protein and in the retinal glia of the second transgenic non-human animal a second fluorescence level of the fluorescent protein.
Dependencies are inferred from the claim text.