Transgenic non-human animal
OwnerRoland John Mayerinventor
Life of this patent
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Abstract
A transgenic non-human animal genetically modified to have a dysfunctional 26S-proteasome in some or all cells, which may exhibit phenotypic and/or neuropathological symptoms similar to those exhibited by individuals with a neurogenerative disorder.
Claims28
A transgenic non-human animal genetically modified to have a dysfunctional 26S-proteasome in some or all cells.
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A transgenic non-human animal comprising one or more 26S proteasome associated ATPase genes which are floxed at least in part, and means to cause expression of the Cre enzyme in some or all cells in the animal, wherein in cells which express the Cre enzyme a dysfunction of the 26S proteasome is observed.
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Dependencies are inferred from the claim text.