Myocardium conditioning using myocardial and parasympathetic stimulation

A system, comprising:

• a neural stimulator adapted to generate a neural stimulation signal;
• a pulse generator adapted to generate a pacing signal to provide myocardium pacing;
• and
• a controller adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy, the conditioning therapy including neural stimulation to elicit a parasympathetic response and myocardium pacing,
• wherein to provide the myocardium pacing for the cardioprotective conditioning therapy, the controller is configured to control the pulse generator to deliver a programmed myocardial pacing sequence,
• wherein the controller is configured to initiate and time a sequence of myocardial pacing pulses for the programmed myocardial pacing sequence,
• wherein the sequence of myocardial pacing pulses includes alternating pacing periods with a programmed pacing duration and non-pacing periods with a programmed non-pacing duration,
• wherein each pacing period in the programmed myocardial pacing sequence includes the timed sequence of myocardial pacing pulses delivered to a myocardium for the duration of each of the pacing periods, and
• wherein myocardial pacing pulses are not delivered during each of the non-pacing periods.