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US 2010/0145298 A1Published application
Oxygen-carrying blood substitute preparations
OwnerNobuaki HORI, Yoshihisa Manabe +4inventors
InventorsNobuaki HORI, Yoshihisa Manabe, Yuko Suka, Toshiya Kai, Seiji Nishida, Naohisa Katayama
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Abstract
An oxygen-carrying blood substitute preparation stable upon storage is provided. The preparation comprises an oxygen-carrying substance capable of reversibly binding and releasing oxygen in vivo and an amount of a physiologically tolerable reducing agent effective for preventing at least partially irreversible oxidation of said oxygen-carrying substance. Preferably the oxygen-carrying substance is a hemoglobin-based substance in the form of a liposome encapsulating hemoglobin.
Claims9
-8. (canceled)
A dual package comprising
- an inner bag filled with the oxygen-carrying blood substitute preparation comprising an oxygen-carrying substance capable of reversibly binding and releasing oxygen in vivo and an amount of a physiologically tolerable reducing agent effective for preventing at least partially irreversible oxidation of said oxygen-carrying composition and
- an outer envelope receiving said inner bag and an oxygen-absorbing agent, said inner bag and said outer envelope being made of a plastic material which is essentially oxygen-impermeable.
Dependencies are inferred from the claim text.