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OwnerHelena Grinberg-Rashi, Gideon Rechavi +2inventors
InventorsHelena Grinberg-Rashi, Gideon Rechavi, Marina Perelman, Shai Izraeli
Estimating the term…
A method of predicting CNS metastasis of a non-neuronal cancer in a subject is disclosed. The method comprises determining a level and/or activity of N-cadherin (CDH2), in a sample of the subject wherein an increase in the CDH2 with respect to an unaffected sample is indicative of the CNS metastasis of the non-neural cancer. The method further comprises determining a level and/or activity or kinesin family member C1 (KIFC1) and/or Fetal Alzheimer Antigen (FALZ1) in the sample wherein an increase in KIFC1 and a decrease in FALZ with respect to an unaffected sample is further indicative of the CNS metastasis of the non-neural cancer. The method may be used for selection of a treatment regimen. In addition, kits for prediction CNS metastasis are disclosed.
A method of predicting central nervous system (CNS) metastasis of a non-neuronal cancer in a subject, the method comprising determining a level and/or activity of N-cadherin (CDH2), in a sample of the subject wherein an increase in said CDH2 with respect to an unaffected sample is indicative of the CNS metastasis of the non-neural cancer.
A method of treating a subject having a non-neuronal cancer, the method comprising:
A kit for predicting CNS metastasis of a non-neuronal cancer in a subject, the kit comprising a packaging material which comprises at least one agent for specifically determining a level and/or activity of no more than one hundred markers, wherein at least one of said one hundred markers is N-cadherin (CDH2).
Dependencies are inferred from the claim text.