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US 2010/0145101 A1Published application
Crystalline solid rasagiline base
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsAnton Frenkel, Tamas Koltai
Life of this patent
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Abstract
The subject invention provides crystalline R(+)-N-propargyl-1-aminoindan, pharmaceutical compositions and methods of manufacture thereof.
Claims17
1-7. (canceled)
A process for manufacture of crystalline R(+)-N-propargyl-1-aminoindan comprising:
- a. dissolving a salt of R(+)-N-propargyl-1-aminoindan in water to form a solution;
- b. cooling said solution to a temperature of about 0-15° C.;
- c. basifying said solution to a pH of about 11 to form a suspension;
- and
- d. obtaining said crystalline rasagiline R(+)-N-propargyl-1-aminoindan from the suspension.
2 more elements
A process for manufacture of crystalline R(+)-N-propargyl-1-aminoindan comprising:
- a. obtaining a first organic solution of liquid R(+)-N-propargyl-1-aminoindan;
- b. completely evaporating the solvent from the first organic solution under vacuum to form a residue;
- c. dissolving the residue in a second organic solvent to form a second organic solution;
- d. completely evaporating the second organic solvent from the second organic solution under vacuum to form a second residue;
- and
- e. maintaining the second residue at a temperature between 0 and 25° C. to form crystalline R(+)-N-propargyl-1-aminoindan.
3 more elements
A process for manufacture of crystalline R(+)-N-propargyl-1-aminoindan comprising:
- a. obtaining a solution of R(+)-N-propargyl-1-aminoindan in a water-soluble organic solvent;
- b. combining the solution with water;
- c. cooling said solution to between 0 and 20° C. to form crystalline R(+)-N-propargyl-1-aminoindan;
- and
- d. isolating the crystalline R(+)-N-propargyl-1-aminoindan.
2 more elements
Dependencies are inferred from the claim text.