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US 2010/0145083 A1Published application
Preparation of bile acids and intermediates thereof
AssigneeKythera Biopharmaceuticals, Inc.
InventorsAchampeta Rathan Prasad, Roy A. Swaringen, JR., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
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Abstract
Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
Claims2
1-15. (canceled)
An intermediate compound selected from the group consisting of
- 9α-Hydroxy-5β-androstan-3,17-dione (1.1);
- 5β-Androst-9(11)-en-3,17-dione (1.2);
- (Z)-3α-Hydroxy-5β-pregna-9(11),17(20)-diene (1.5);
- (Z)-3α-Acetoxy-5β-pregna-9(11),17(20)-diene (1.6);
- (E)-Methyl 3α-acetoxy-5β-chol-9(11), 16, 22-trien-24-oate (1.7a);
- Methyl 3α-acetoxy-5β-chol-9(1 1), 16-dien-24-oate (1.7b);
- Methyl 3α-acetoxy-5β-chol-9(11)-en-12-one-24-oate (1.9a);
- and
- Methyl 3α-acetoxy-5β-cholan-12-one-24-oate (2.0a).
6 more elements
Dependencies are inferred from the claim text.