2,4-Disubstituted-5-Aminocarbonyl-1,3-Thiazole Derivatives For Therapeutic Agent Of Antiinflammatory Disease, Method Thereof For Preparation, Therapeutic Agent For Antiinflammatory Disease Induced By SPC Activity Containing The Same

A 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivative represented by the following formula 1:

• wherein R1 and R2 are the same or different and are each a C1-C10 linear, branched or cyclic alkyl group, or a cyclic C1-C10 alkyl group containing a heteroatom (—NH—, —S— or —O—) or heteroalkyl group, R3 is a carbonyl group containing at least one of a C1-C10 linear, branched or cyclic alkyl group, a C1-C10 alkoxy group, a C2-C10 alkenyl group, a C2-C10 alkynyl group, a heteroaryl group, an arylalkyl group, a C5-C10 heteroarylalkyl group, a phenyl or a substituted phenyl group, and R4 is an amino group substituted with one or more of a C1-C10 linear, branched or cyclic alkyl group, a C1-C10 aryl group, a C1-C10 heteroaryl group, a C1-C10 arylalkyl group or heteroarylalkyl group, or an amine containing a piperazine substituted with a C1-C10 linear, branched or cyclic alkyl group, a phenyl or a substituted phenyl or a heteroarylamide group, wherein the substituted phenyl group in R3 and R4 represents a phenyl group substituted with 1 to 4 substituents selected from the group consisting of a halogen atom, a nitro group, a C1-C10 alkyl group, a C1-C10 alkoxy group and a C1-C10 haloalkyl group.