Methods for producing antibodies from plasma cells
AssigneeInstitute for Research in Biomedicine
InventorsAntonio Lanzavecchia, David Jarrossay
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Abstract
The invention relates to methods of producing antibodies, including monoclonal antibodies, comprising culturing a limited number of plasma cells. It also relates to methods of identifying antibodies by performing assays on the antibodies produced by the cultured plasma cells to determine their function, binding specificity, epitope specificity, and/or their ability to neutralize a toxin or a pathogen. The invention also relates to antibodies and antibody fragments produced by the methods of the invention as well as methods of using the antibodies and antibody fragments.
Claims22
A method of producing an antibody from plasma cells comprising:
- culturing the plasma cells in limited numbers.
A method of producing a monoclonal antibody from plasma cells comprising:
- culturing the plasma cells in single cell cultures.
Dependencies are inferred from the claim text.