Gene encoding a multidrug resistance human p-glycoprotein homologue on chromosome 7p15-21 and uses thereof
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsMARKUS H. FRANK, MOHAMED H. SAYEGH
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Abstract
The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
Claims21
1-7. (canceled)
An isolated antibody or functional fragment thereof that selectively binds to a protein comprising SEQ ID NO:
- 2.
An isolated antibody or functional fragment thereof specific for a protein encoded by a nucleotide sequence comprising SEQ ID NO:
- 10.
An isolated oligonucleotide that acts as an antisense inhibitor of P-glycoprotein expression, wherein said oligonucleotide is at least 15 nucleotides in length and consists of a sequence complementary to at least 15 contiguous nucleotides in SEQ ID NO:
- 10.
Dependencies are inferred from the claim text.