Method of Isolating Biomacromolecules Using Low pH and Divalent Cations
AssigneeBiogen Idic Ma Inc.
InventorsJonathan Romero, James Chrostowski, Philippe Georges De Vilmorin, Jennifer Yun Case
Life of this patent
Estimating the term…
Abstract
The present invention is related to a method of isolating a biological macromolecule in a composition. Specifically, the present invention is directed to a method of isolating a biomacromolecule in a composition containing an impurity, the method comprising (a) lowering the pH of the composition, (b) adding a divalent cation to the composition, and (c) separating the biomacromolecule from the impurity.
Claims33
A method of isolating a biomacromolecule in a composition containing an impurity, the method comprising:
- (a) lowering the pH of said composition;
- (b) adding a divalent cation to said composition;
- and
- (c) separating said biomacromolecule from said impurity.
A method of purifying a biomacromolecule in a composition containing an impurity, the method comprising:
- (a) lowering the pH of said composition;
- (b) adding a divalent cation to said composition;
- and
- (c) separating said biomacromolecule from said impurity.
A method of clarifying a composition containing a biomacromolecule and an impurity, the method comprising:
- (a) lowering the pH of said composition;
- (b) adding a divalent cation to said composition;
- and
- (c) separating said biomacromolecule from said impurity.
Dependencies are inferred from the claim text.