Lipid-Polymer-Conjugates

A lipid-polymer conjugate consisting of (a) an amphiphilic liquid having at least one hydrophobic apolar moiety and a hydrophilic polar head group and (b) a polymer or a monomeric precursor thereof,

• wherein the polymer is selected from the group consisting of poly[N-(2-hydroxyethyl)-L-glutamine];
• poly[N-(2-hydroxypropyl)-L-glutamine];
• poly[(2-hydroxyethyl)-L-asparagine];
• poly(DL-glutamine);
• poly(DL-asparagine);
• copolypeptide of β-alanine and hydroxyethyl-L-glutamine;
• poly[N-(2-hydroxyethyl)-L-glutamine-co-dimethylaminoethylglutamine];
• and poly(D,L-methionine sulfoxide), and
• wherein the amphiphilic lipid contains at least two hydrophobic apolar moieties and is selected from the group consisting of 1-heptadecyloctadecylamine;
• N-succinyldioctadecylamine;
• and distearylphosphatidylethanolamine.

Use of a polymer selected from the group consisting of poly[N-(2-hydroxyethyl)-L-glutamine];

• poly[N-(2-hydroxypropyl)-L-glutamine];
• poly[(2-hydroxyethyl)-L-asparagine];
• poly(DL-glutamine);
• poly(DL-asparagine);
• copolypeptide of β-alanine and hydroxyethyl-L-glutamine;
• poly[N-(2-hydroxyethyl)-L-glutamine-co-dimethylaminoethylglutamine];
• and poly(D,L-methionine sulfoxide) for preparing a lipid-polymer conjugate,
• wherein the lipid is an amphiphilic lipid containing at least two hydrophobic apolar moieties and is selected from the group consisting of 1-heptadecyloctadecylamine;
• N-succinyldioctadecylamine and distearylphosphatidylethanolamine, and
• wherein the lipid-polymer conjugate, when present at a sufficient molar concentration in a colloidal carrier composition, extends the blood circulation time of said colloidal carrier composition as compared to a colloidal carrier composition containing the amphiphilic lipid only.