System and process for the synthesis of polymers
OwnerAlain LAURENT, Philippe Sarra-Bournet +4inventors
InventorsAlain LAURENT, Philippe Sarra-Bournet, Olivier Aude, Paul Morgavi, Bernard Mandrand, Marc Cuzin
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Abstract
The present invention relates to an automated polymer synthesis apparatus for synthesizing a polymer chain onto a solid substrates by sequentially adding polymer building blocks as well as to a method for synthesizing polymers on solid substrates by sequentially reacting polymer building blocks with reactive groups. The invention further relates to a biochip comprising a solid substrate with reactive groups where biomolecules are attached to and the remaining reactive groups are transformed into chemically inert species.
Claims12
1-9. (canceled)
A method for synthesizing a polymer on a solid substrate comprising the sequential reaction of polymer building blocks comprising reactive groups protected with removable protecting groups comprising the following steps:
- a) providing a polymeric surface whereby the polymeric surface comprises functional groups,
- b) applying a first microdroplet comprising a first polymer building block on said surface,
- c) reacting the first polymer building block with a functional group of the polymeric surface thereby attaching the first polymer building block to the polymeric surface,
- d) removing a protecting group of the attached polymer building block
- e) applying onto said first microdroplet a second microdroplet comprising a second polymer building block, which is the same or different from the first polymer building block,
- f) reacting said second polymer building block with the deprotected reactive group of the first polymer building block, and
- g) optionally, sequentially repeating steps d)-f).
- wherein after step c) the unreacted functional groups of the polymeric surface are transformed into chemically inert species,
- and wherein the diameter of the first microdroplet is smaller than the diameter of the second microdroplet.
(canceled)
19-23. (canceled)
Dependencies are inferred from the claim text.