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US 2010/0145011 A1Published application
Alpha-conotoxin peptides
AssigneesUniversity of Utah Research Foundation, Cognetix, Inc.
InventorsMaren WATKINS, Baldomero M. OLIVERA, David R. HILLYARD, J. Michael MCINTOSH, Robert M. JONES
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Abstract
The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
Claims6
An isolated α-conotoxin peptide having the generic formula III:
- Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Cys-Cys-Xaa6-Xaa7-Xaa8-Xaa9-Cys-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-Xaa15-Xaa16-Cys-Xaa17-Xaa18-Xaa19-Xaa20-Xaa21-Xaa22-Xaa23-Xaa24 (SEQ ID NO:3), wherein Xaa1 is des-Xaa1, Xaa2 is des-Xaa2, Xaa3 is des-Xaa3, Xaa4 is Asp, Xaa5 is Glu or Gla, Xaa6 is Ser, Xaa7 is Asn, Xaa8 is Pro or hydroxy-Pro, Xaa9 is Ala, Xaa10 is Arg, Xaa11 is Leu, Xaa12 is Asn, Xaa13 is Asn, Xaa14 is Pro or hydroxy-Pro, Xaa15 is His, Xaa16 is Ala or Val, Xaa17 is Arg, Xaa18 is Arg, Xaa19 is Arg, Xaa20 is des-Xaa20, Xaa21 is des-Xaa21, Xaa22 is des-Xaa22, Xaa23 is des-Xaa23 and Xaa24 is des-Xaa24;
- wherein the C-terminus contains a hydroxyl group or an amide group;
- wherein the His residue may be substituted with a halo-His residue;
- wherein an Arg residue may be substituted with homoarginine;
- and wherein the Cys residues may be in the D or L configuration or substituted with homocysteine in the D or L configuration.
2 more elements
Dependencies are inferred from the claim text.