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US 2010/0145010 A1Published application
Functional enhancement of antimicrobials
AssigneeMississippi State University
InventorsJames L. Smith, Ravi Orugunty
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Abstract
The present invention provides methods for adding functional hydrophobic, charge, polar, and other structural groups on antimicrobial compounds for enhancing the physicochemical properties of the antimicrobial compounds, thereby creating novel antimicrobial analogs with enhanced functions.
Claims22
A method of improving the functionality of antimicrobial compounds, the method comprising:
- combining at least one thiol organosulfur compound with an antimicrobial compound in a reaction mixture for enhancing the physicochemical properties of the antimicrobial compound, wherein the reaction mixture composition is determined by the solubility of the antimicrobial compound and the at least one thiol organosulfur compound;
- combining the antimicrobial compound with at least one compound of a functional group in the reaction mixture for enhancing the minimum inhibitory concentrations of the antimicrobial compound against selected organisms;
- optimizing the molar ratio of the combination of the at least one thiol organosulfur compound and the antimicrobial compound;
- optimizing the rate and temperature of the reaction mixture;
- and
- controlling the rate of the reaction mixture by adjusting the molar ratio of the at least one thiol organosulfur compound to the antimicrobial compound.
3 more elements
A method of purification of active pharmaceutical ingredients, the method comprising:
- obtaining an antimicrobial compound from a complex mixture of organic and inorganic compounds, wherein the antimicrobial compound is an active pharmaceutical ingredient;
- and
- labeling the antimicrobial compound with a thiol organosulfur compound tag for facilitating further purification of the ingredient from the complex mixture of organic and inorganic compounds.
A method of improving the functionality of antimicrobial compounds, the method comprising:
- combining at least one thiol organosulfur compound with an antimicrobial compound in a reaction mixture, wherein the at least one thiol organosulfur compound comprises a functional group for enabling additional chemistry coupling reactions and for producing additional analog antibiotic compounds.
Dependencies are inferred from the claim text.